Giants fans quickly took to Twitter to lament their injury woes and wish Beckham Jr a speedy recovery.
According to early reports, he'll have surgery on what could be a broken fibula.
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It was immediately clear that Beckham was in severe pain as players around him signaled to the sideline and he rolled around in tears. With the Giants falling to 0-5 after the loss to the Los Angeles Chargers, it would be surprising if Beckham played again in 2017.
Beckham had eight catches for 68 yards before being injured. And the Giants went on to lose the game. Through his first three games, Beckham had put up 20 receptions for 205 yards and two touchdowns.